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Progesterone - Overview
Progesterone is a natural steroid hormone available as a prescription medication. It is frequently prescribed for endometrial protection in women taking estrogen, for secondary amenorrhea, and for fertility support. Women who need a progesterone medication prescription can connect with a medical provider through Push Health who can prescribe micronized progesterone capsules (and other forms) when appropriate to do so.
What Is Progesterone Used For?
Progesterone prescription medication, marketed under the brand Prometrium and others, is sometimes prescribed to women with perimenopause symptoms, fertility issues, and amenorrhea. Progesterone is a type of steroid hormone and is also an ingredient in certain kinds of birth control medications. Progesterone prescription medication is very similar in structure and effect to the medication medroxyprogesterone. Progesterone medication is combined with the medication estradiol in the medication Bijuva. Progesterone medication plays a role in the health of the uterine lining and may also be involved in mood and stress.
Progesterone - Dosage and Cost
Common oral micronized progesterone regimens are as follows:
- Cyclic (with estrogen): 200 mg at bedtime for 12-14 days per month.
- Continuous combined: 100 mg (sometimes 200 mg) daily at bedtime.
- Amenorrhea: often 400 mg daily for 10 days (per some labeling).
Oral capsules are typically taken at bedtime because of mild sedative effects. Patients should discuss the right prescription plan for them with their medical provider.
Generic micronized progesterone is relatively affordable, often costing well under $1 per 100 mg capsule at many pharmacies. Insurance frequently covers it and coupons and savings cards can further reduce cost.
The progesterone medication used in branded products is generally made from plant sources. In the body, progesterone prescription medication is excreted via the bile and kidneys after primarily undergoing hepatic metabolism to pregnanediol and pregnanolone metabolites. Progesterone medication is micronized prior to use in capsules.
Progesterone - Capsules, Creams and Suppositories
| Form | Uses | Dosing | Absorption |
|---|---|---|---|
| Oral micronized capsules | Endometrial protection / HRT | Daily | Systemic |
| Cream | Symptom management | 1-2 times / day | Local (mostly) |
| Vaginal (suppository / gel / insert) | Fertility / luteal support | 1-3 times / day | Local |
How to Get a Progesterone Prescription with Push Health
- Complete a brief health intake. Answer questions about your symptoms, current medications, whether you are taking or considering estrogen, and relevant medical history.
- Connect with a licensed medical provider. A provider will review your information and evaluate which form of progesterone is most appropriate for your situation. Same-day consultations are available.
- Receive your prescription electronically. If progesterone is appropriate, your provider will send a prescription to a pharmacy of your choice - no office visit required.
- Pick up your medication. Generic micronized progesterone 100 mg capsules are available at most pharmacies. No health insurance or subscription is required.
Medical providers are available now.
Frequently Asked Questions about Progesterone
What is progesterone used for?
Progesterone is most commonly used in women with a uterus who take systemic estrogen (HRT), treatment of secondary amenorrhea, and fertility support. It may also help with sleep in perimenopausal women when taken at bedtime.
Do I need to take progesterone if I am taking estradiol medication?
Yes, if you still have your uterus. System estrogen without adequate progesterone increases the risk of endometrial hyperplasia and cancer. Women who have had a hysterectomy generally do not need progesterone for uterine protection.
What is the difference between progesterone and progestin?
Progesterone generally refers to bioidentical (micronized) progesterone which is considered identical to the hormone the body naturally produces. In contrast, progestins (e.g. medroxyprogesterone) are synthetic and have different structures and safety profiles. Many clinicians prefer micronized progesterone for HRT.
Can progesterone help with sleep?
Yes. Oral micronized progesterone medication has a mild sedative effect in some women due to its metabolites. When taken at bedtime, it can improve sleep quality, particularly for women in perimenopause and menopause.
How long does it take for progesterone to work?
Sleep-related benefits may appear within 2-4 weeks. Endometrial protection is ongoing with consistent use as prescribed.
What is the difference between progesterone capsules and progesterone cream?
Oral capsules provide reliable systemic levels and are considered the standard for endometrial protection. Creams (especially compounded) have variable absorption and are generally not recommended when uterine protection is required.
Does insurance cover costs associated with progesterone medication?
Many insurance plans cover the costs associated with progesterone medication although a prior authorization might be required. For people paying out of pocket, generic progesterone medication is typically moderately affordable.
Is bioidentical progesterone available through Push Health?
Yes. Medical providers can prescribe micronized progesterone capsules (generic or brand) when appropriate. Discuss your goals and medical history during your evaluation.
Why is progesterone often taken at bedtime?
Oral micronized progesterone is converted in part to neurosteroids that have mild sedative and anxiolytic properties by acting on GABA receptors in the brain. This is why oral progesterone taken at bedtime can improve sleep quality and reduce nighttime waking in perimenopausal and menopausal women. Taking progesterone at night also helps minimize daytime drowsiness. Patients who experience difficulty sleeping as a perimenopause symptom often find that bedtime progesterone dosing addresses both their need for uterine protection and their sleep concerns simultaneously.
What is the difference between progesterone and medroxyprogesterone acetate?
Medroxyprogesterone acetate (MPA) is a synthetic progestin with a different molecular structure from natural progesterone. The WHI study findings that raised concerns about HRT used conjugated equine estrogen combined with MPA. Bioidentical progesterone is not the same as MPA and has a different safety profile. In particular, bioidentical progesterone does not appear to carry the same breast cancer risk signal associated with synthetic MPA. Many providers now prefer bioidentical progesterone over synthetic progestins for this reason. Questions about this distinction should be directed to one's medical provider when evaluating HRT options.
Can progesterone levels increase using alternative treatments?
Some women try phytoestrogens, supplements, and lifestyle changes to improve progesterone levels. While these interventions might be helpful, they are typically less effective than prescription progesterone medication. Patients should discuss natural alternatives with their medical provider before making any treatment plan changes.
Who Can Use Progesterone?
Progesterone medication is prescribed to adult women for hormonal indications, most often alongside estrogen for uterine protection during perimenopause or menopause, or for amenorrhea and fertility support. It should generally be avoided in women with a history of breast cancer, blood clots, stroke, significant liver disease, unexplained vaginal bleeding, or known/suspected pregnancy. A full medical history is required before prescribing.
Progesterone - Side Effects
Progesterone prescription medication can cause side effects in patients, including headaches, mood changes, nausea, breast tenderness, dizziness and abdominal pain. Side effects from progesterone use can vary from person to person. Care should be taken when progesterone is used in combination with other hormones.
Progesterone medication should not be used by women with abnormal genital bleeding, a history of breast cancer, thromboembolism, liver disease or a known or suspected pregnancy. Alcohol should be used with caution while taking oral progesterone as it can enhance sedative effects. Questions and concerns about the side effects related to progesterone medication use should be directed to one's pharmacist and medical provider before use.
More Progesterone Information
Last updated August 12, 2026. Given the evolving nature of medicine and science, this information might not be accurate and should not be construed as medical advice or diagnosis / treatment recommendations. Please consult a licensed medical provider if you have additional questions. Please call 911 immediately or go to the nearest emergency room if you believe you are experiencing a medical emergency.