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Perimenopause Treatment - Overview

Perimenopause treatment medications are sometimes prescribed to women who are experiencing symptoms of perimenopause. Women who might need prescription medications for perimenopause treatment can use Push Health to connect with a medical provider who can prescribe perimenopause medications when appropriate to do so. Please note that Push Health does not prescribe testosterone at this time.

What Is Perimenopause Treatment?

Perimenopause treatment consists of prescription hormone medications such as estradiol and progesterone that are prescribed to women who need help with symptoms related to perimenopause - similar to hormone replacement therapy (HRT). Perimenopause is a complex disorder that is increasingly recognized as the cause for a variety of symptoms in women ages 30 and up, including hot flashes, mood disorders, insomnia, night sweats, joint pain, cognitive symptoms, migraines, and more. Perimenopause medication treatment is thought to work by helping a woman restore hormones that might have decreased during perimenopause in order to achieve symptom relief.

Perimenopause Medications - Dosage and Cost

The types of hormones used during perimenopause treatment typically vary in dosage and the regimen used. Many perimenopause hormones are applied transdermally or taken orally. Perimenopause treatment medications are considered relatively affordable as some of the medications are available in generic versions. Additionally, some insurance plans may help cover costs associated with perimenopause treatment prescriptions when buying perimenopause medications at a pharmacy.

Can I Buy Perimenopause Medications Online?

Perimenopause treatment medications - especially hormone-based ones - require a prescription to be dispensed by a pharmacy in the United States. As a result, perimenopause medications are not available OTC (over the counter) and one cannot just buy perimenopause medications online without first getting a prescription from a licensed medical provider. Women who might need perimenopause treatment, however, can use Push Health to connect with a medical provider who can prescribe perimenopause medications when appropriate to do so.

Frequently Asked Questions about Perimenopause Treatment

What is perimenopause?

Perimenopause is the transitional phase before menopause during which estrogen and progesterone levels fluctuate and decline. It typically begins in a woman's 40s and lasts 4 to 8 years before the final menstrual period. During this time, hormonal changes cause a wide range of symptoms including hot flashes, night sweats, sleep disturbances, mood changes, irregular periods, and vaginal dryness.

How long does perimenopause last?

Perimenopause typically lasts 4 to 8 years, though it can be shorter or longer. It ends when a woman has gone 12 consecutive months without a menstrual period - at which point she has reached menopause. The most intense symptoms often occur in the 1 to 2 years immediately before and after the final period.

What medications are used for perimenopause?

The primary medications used for perimenopause treatment are estradiol (bioidentical estrogen) and progesterone. Estradiol is available as patches, gels, sprays, oral tablets, and vaginal preparations. Progesterone is typically prescribed alongside estradiol for women who still have their uterus. Bijuva combines both in a single daily capsule. Non-hormonal options including certain antidepressants and gabapentin can also be used for specific symptoms.

Can I start hormone therapy during perimenopause?

Yes. Hormone therapy can be started during perimenopause - patients do not need to wait until menopause. In fact, starting hormone therapy during the perimenopausal window may confer cardiovascular and other health benefits that are less pronounced if treatment is delayed until years after menopause. A licensed provider can evaluate whether hormone therapy is appropriate based on individual symptoms, medical history, and risk factors.

Is estradiol safe for perimenopause?

For most healthy women in their 40s and early 50s without contraindications, estradiol is considered safe and effective for managing perimenopausal symptoms. The February 2026 FDA removal of the black box warning from bioidentical estradiol patches, gels, and creams reflects updated recognition of the improved safety profile of these formulations when used appropriately. Women with a personal history of certain estrogen-sensitive cancers, blood clots, or stroke should discuss these risks with their provider before starting estradiol.

Do I need progesterone if I'm taking estradiol?

Women with an intact uterus who are taking systemic estradiol need progesterone to protect the uterine lining from the stimulating effects of estrogen alone, which can otherwise increase the risk of endometrial cancer. Women who have had a hysterectomy do not need progesterone. Women using only local vaginal estrogen (cream, tablet, or ring) for vaginal dryness typically do not need systemic progesterone. A provider will advise on whether progesterone is needed based on individual circumstances.

Can I get perimenopause treatment if I'm still having periods?

Yes. Many women seek and receive perimenopause treatment while still having irregular periods. Irregular cycles are a hallmark of perimenopause and are not a contraindication to treatment. A licensed provider can evaluate symptoms, confirm that perimenopause is a likely diagnosis, and prescribe appropriate treatment while a woman is still having periods.


Perimenopause - Lifestyle Modifications

Lifestyle and diet modifications may also be beneficial in helping with perimenopausal symptoms.

Perimenopause Treatment - Side Effects

Prescription medications used for treating perimenopause symptoms can cause side effects when used. Before using medications to help with perimenopause symptoms, it is important to discuss potential side effects and other concerns with a qualified medical provider. Perimenopause medications and alcohol should generally not be used together. People with a hypersensitivity or allergy to perimenopause medications will need to discuss alternatives with their medical provider.

How to Get Perimenopause Treatment with Push Health

  1. Complete a brief health intake. Answer a few questions about your symptoms, menstrual history, current medications, and relevant medical history - including any personal or family history of breast cancer, blood clots, or cardiovascular disease.
  2. Connect with a licensed medical provider. A provider will review your information and evaluate which perimenopause treatment - estradiol form, progesterone, combination therapy, or non-hormonal options - is most appropriate for your situation. Same-day consultations are available.
  3. Receive your prescription electronically. If hormone therapy is appropriate, your provider will send a prescription to a pharmacy of your choice - no office visit required.
  4. Pick up your medication or have it delivered. Generic estradiol and progesterone are available at most retail pharmacies at affordable prices. The estradiol patch shortage has made gels and oral tablets more readily available - your provider can prescribe the most accessible form. No health insurance or subscription is required.

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More Perimenopause Treatment Information

Last updated August 5, 2026. Given the evolving nature of medicine and science, this information might not be accurate and should not be construed as medical advice or diagnosis / treatment recommendations. Please consult a licensed medical provider if you have additional questions. Please call 911 immediately or go to the nearest emergency room if you believe you are experiencing a medical emergency.